GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs710865 | 1 | rs710865 | chr1:19568972 | KIAA0090 | chr1:19544585-19578046:- | -0.29 | -9.65 | 2.9E-20 | Brain structure |
| THCA | cis | rs710865 | 1 | rs710866 | chr1:19568722 | CAPZB | chr1:19665274-19811992:- | 0.12 | 3.52 | 0.000475 | Brain structure |
| THCA | cis | rs710865 | 1 | rs710866 | chr1:19568722 | KIAA0090 | chr1:19544585-19578046:- | -0.29 | -9.67 | 2.58E-20 | Brain structure |
| THCA | cis | rs7951870 | 1 | rs7109698 | chr11:46673344 | PACSIN3 | chr11:47199085-47207958:- | -0.15 | -3.57 | 0.000395 | Schizophrenia |
| THCA | cis | rs2028299 | 1 | rs7111 | chr15:90373873 | AP3S2 | chr15:90373832-90456222:- | -0.75 | -18.8 | 1.86E-59 | Type 2 diabetes |
| THCA | cis | rs2028299 | 1 | rs7111 | chr15:90373873 | C15orf38 | chr15:90443832-90456222:- | 0.36 | 7.6 | 1.54E-13 | Type 2 diabetes |
| THCA | cis | rs7107174 | 1 | rs7111986 | chr11:78102266 | NARS2 | chr11:78147017-78285909:- | -0.4 | -7.05 | 6.34E-12 | Testicular germ cell tumor |
| THCA | cis | rs7951870 | 1 | rs7112229 | chr11:46513249 | PACSIN3 | chr11:47199085-47207958:- | 0.17 | 3.88 | 0.000121 | Schizophrenia |
| THCA | cis | rs7107174 | 1 | rs7112234 | chr11:78102470 | NARS2 | chr11:78147017-78285909:- | -0.38 | -7.1 | 4.55E-12 | Testicular germ cell tumor |
| THCA | cis | rs7112513 | 1 | rs7112513 | chr11:117037361 | PCSK7 | chr11:117075789-117102811:- | -0.38 | -6.66 | 7.48E-11 | Protein quantitative trait loci |
| THCA | cis | rs7107174 | 1 | rs7113042 | chr11:78035832 | NARS2 | chr11:78147017-78285909:- | 0.37 | 6.99 | 9.18E-12 | Testicular germ cell tumor |
| THCA | cis | rs7116495 | 1 | rs7113549 | chr11:71829967 | FAM86C | chr11:71498557-71512276:+ | -0.31 | -3.95 | 8.86E-5 | Severe influenza A (H1N1) infection |
| THCA | cis | rs3829251 | 1 | rs7114252 | chr11:71237606 | NADSYN1 | chr11:71164217-71212579:+ | 0.18 | 4.11 | 4.67E-5 | Vitamin D levels |
| THCA | cis | rs7112513 | 1 | rs7114963 | chr11:116875983 | PCSK7 | chr11:117075789-117102811:- | -0.29 | -5.09 | 5.09E-7 | Protein quantitative trait loci |
| THCA | cis | rs4237643 | 1 | rs7115737 | chr11:43681249 | HSD17B12 | chr11:43702143-43878160:+ | -0.69 | -14.36 | 4.1E-39 | Forced vital capacity |